Abstract
GLUCURONIDE conjugates are formed by the condensation of an alcohol or acid aglycone with uridine diphosphoglucuronic acid by the enzyme, glucuronosyl transferase1. A functional immaturity of this enzyme system and perhaps a deficiency of uridine diphosphoglucuronic acid has been observed in new-born animals2. Since indirect-reacting bilirubin is converted to bilirubin glucuronide by means of glucuronosyl transferase3, Billing et al. 4 have suggested that physiological hyperbilirubinæmia of the new-born infant might be the result of a deficiency of this enzyme system. Recently, Lathe and Walker5 reported inhibition of bilirubin conjugation in liver slices by serum of pregnant women. This communication reports studies aimed at identifying the inhibitor substances and assessing their importance in hyperbilirubinæmia of the new-born.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dutton, G. J., and Storey, I. D. E., Biochem. J., 57, 275 (1954). Storey, I. D. E., and Dutton, G. J., ibid., 59, 279 (1955). Dutton, G. J., ibid., 64, 693 (1956).
Karunairatnam, M. D., Kerr, L. M. H., and Levvy, G. A., Biochem. J., 45, 496 (1949). Brown, A. K., and Zuelzer, W. W., J. Clin. Invest., 37, 332 (1958). Lathe, G. H., and Walker, M., Biochem. J., 70, 705 (1958). Dutton, G. J., ibid., 71, 141 (1959).
Schmid, R., Science, 124, 76 (1956). Schmid, R., Hammaker, L., and Axelrod, J., Arch. Biochem., 70, 285 (1957). Cole, P. G., Lathe, G. H., and Billing, B. H., Biochem. J., 57, 514 (1954). Billing, B. H., Cole, P. G., and Lathe, G. H., ibid., 65, 774 (1957). Grodsky, G. M., and Carbone, J. V., J. Biol. Chem., 226, 449 (1957).
Billing, B. H., Cole, P. G., and Lathe, G. H., Brit. Med. J., ii, 1263 (1954).
Lathe, G. H., and Walker, M., Quart. J. Exp. Phys., 43, 257 (1958).
Levvy, G. A., and Storey, I. D. E., Biochem. J., 44, 295 (1949).
Savard, K., “Recent Prog. Hormone Res.”, 9, 185 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
YI-YUNG HSIA, D., DOWBEN, R., SHAW, R. et al. Inhibition of Glucuronosyl Transferase by Progestational Agents from Serum of Pregnant Women. Nature 187, 693–694 (1960). https://doi.org/10.1038/187693a0
Issue Date:
DOI: https://doi.org/10.1038/187693a0
This article is cited by
-
Das Verhalten der Steroidausscheidung und des Serum-Bilirubinspiegels bei Neugeborenen nach C19-Steroid-Belastung
Archiv f�r Gyn�kologie (1970)
-
Serum-Bilirubinwerte und Steroidausscheidung bei mit 3?,20?- und 3?,20?-Pregnandiol belasteten Neugeborenen
Archiv f�r Gyn�kologie (1970)
-
Der Steroidgehalt der Frauenmilch
Archiv f�r Gyn�kologie (1969)
-
Neugeborenenhyperbilirubin�mie und Schwangerschaftsgestose
Zeitschrift f�r Kinderheilkunde (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.