Excretion of Catechol after Ingestion of Quinic and Shikimic Acids

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Abstract

THE detection of catechol in acid-hydrolysed normal human urine and cow's urine was reported recently by von Euler and Lishajko1. The origin of the catechol was not known. The excretion of hippuric acid in the urine of man after oral ingestion of calcium quinate was reported by Lautemann in 18632. It occurred to us that if an aromatic ring can be formed in the animal body from quinic acid (1 : 3 : 4 : 5-tetrahydroxycyclohexane carboxylic acid), then urinary catechol might have a similar origin. Further, an exogenous (dietary) precursor is implicated since we are unable to detect catechol in the urine of rats fed a highly purified diet. Quinic and shikimic acids are known to be present in edible plants.

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References

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    Euler, U. S. v., and Lishajko, F., Nature, 183, 1123 (1959).

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BOOTH, A., ROBBINS, D., MASRI, M. et al. Excretion of Catechol after Ingestion of Quinic and Shikimic Acids. Nature 187, 691 (1960) doi:10.1038/187691a0

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