Antibody Responses of the Domestic Fowl to Two Soluble Bacterial Antigens

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FOR some years now virologists have recognized the value of the domestic fowl as a means of obtaining high-titred antisera to viral and rickettsial antigens. Bacteriologists and immunologists have almost invariably preferred the rabbit, consequently little information is available about the responses of fowls to soluble bacterial antigens. While investigating the immunological tolerance of diphtheria alumprecipitated toxoid in the domestic fowl1 I had the opportunity of collecting a limited amount of information about the primary and secondary antibody responses of White Leghorn fowls to both tetanus alumprecipitated toxoid (Wellcome series W6874A) and diphtheria alum-precipitated toxoid (Wellcome series BA6403A) ; though only one dosage of each antigen was used, the results may be of value to other workers.

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    Gowland, G., and Oakley, C. L., J. Path. Bact. (in the press).

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    Romer, P. H., and Sames, T., Z. ImmunForsch., 3, 334 (1909).

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    Glenny, A. T., and Llewellyn-Jones, Mona, J. Path. Bact., 34, 143 (1931).

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    Glenny, A. T., and Stevens, Muriel, F., J. Roy. Army Med. Corps, 70, 308 (1938).

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GOWLAND, G. Antibody Responses of the Domestic Fowl to Two Soluble Bacterial Antigens. Nature 187, 624 (1960) doi:10.1038/187624a0

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