A Growth Factor for Haemophilus Species secreted by a Pseudomonad

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THE clustering of bacterial colonies of one species around those of another—satellitism—was first described for Haemophilus influenzae by Grassberger in 18971. The interrelationship is probably due to the supply of critical nutrients by one micro-organism to the other. While the special nutritional requirements of Haemophilus species have been studied and some compounds essential for growth identified2, the nature of bacterial substances responsible for the satellite phenomenon have not been investigated. In this communication we report on the isolation of such substances.

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  1. 1

    Grassberger, R., Z. Hyg. Infekt. Dis., 25, 453 (1897).

  2. 2

    Lwoff, A., Ann. Inst. Pasteur, 61, 580 (1938).

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    Gingrich, W., and Schlenk, F., J. Bact., 47, 535 (1944).

  4. 4

    Dorfman, A., Koser, S. A., Reames, H. R., Swingle, K. F., and Saunders, F., J. Infect. Dist., 65, 163 (1939).

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SHIFRINE, M., BIBERSTEIN, E. A Growth Factor for Haemophilus Species secreted by a Pseudomonad. Nature 187, 623 (1960) doi:10.1038/187623a0

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