Radiosensitivity of Mouse Kidney undergoing Compensatory Hypertrophy

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Abstract

WE have been interested in assessing the degree or extent of acute radiation damage to the kidneys, particularly as it may relate to late radiation effects on this organ, namely nephrosclerosis1,2. Significant acute changes in renal morphology (that is, during the first month), following whole-body irradiation in the lethal dose-range, have not in general been observed3,4. In this connexion, it is well known that the kidney of the normal adult exhibits only minimal mitotic activity. Therefore it was thought of interest to ascertain whether the kidney becomes radiosensitive when mitotic activity is stimulated by unilateral nephrectomy. Mitotic activity of the kidney following unilateral nephrectomy has been shown by Rollason5 and by Sulkin6 to be largely restricted to the period 48–72 hr. post-surgery.

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References

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ROSEN, V., COLE, L. Radiosensitivity of Mouse Kidney undergoing Compensatory Hypertrophy. Nature 187, 612–614 (1960) doi:10.1038/187612b0

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