Radiosensitivity of Mouse Kidney undergoing Compensatory Hypertrophy

Article metrics


WE have been interested in assessing the degree or extent of acute radiation damage to the kidneys, particularly as it may relate to late radiation effects on this organ, namely nephrosclerosis1,2. Significant acute changes in renal morphology (that is, during the first month), following whole-body irradiation in the lethal dose-range, have not in general been observed3,4. In this connexion, it is well known that the kidney of the normal adult exhibits only minimal mitotic activity. Therefore it was thought of interest to ascertain whether the kidney becomes radiosensitive when mitotic activity is stimulated by unilateral nephrectomy. Mitotic activity of the kidney following unilateral nephrectomy has been shown by Rollason5 and by Sulkin6 to be largely restricted to the period 48–72 hr. post-surgery.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Furth, J., Upton, A. C., Christenberry, K. W., Benedict, W. H., and Moshman, J., Radiology, 63, 562 (1954).

  2. 2

    Cole, L. J., Nowell, P. C., and Ellis, M. E., J. Nat. Cancer Inst., 17, 435 (1956).

  3. 3

    Patt, H. M., and Brues, A. M., in “Radiation Biology”, 1, Pt. 2, edit. by Hollander, A., 959 (McGraw-Hill, New York, 1954).

  4. 4

    Warren, S., Arch. Path., 34, 1079 (1942).

  5. 5

    Rollason, H. D., Anat. Rec., 104, 263 (1949).

  6. 6

    Sulkin, N. M., Anat. Rec., 105, 95 (1949).

  7. 7

    Becker, N. H., and Ogawa, K., J. Biophys. Biochem. Cytol., 6, 297 (1959).

  8. 8

    Beltz, R. E., and Applegate, R. L., Biochem. Biophys. Res. Communications, 1, 298 (1959).

  9. 9

    Bollum, F., and Potter, V. R., Cancer Res., 19, 561 (1959).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

ROSEN, V., COLE, L. Radiosensitivity of Mouse Kidney undergoing Compensatory Hypertrophy. Nature 187, 612–614 (1960) doi:10.1038/187612b0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.