Anti-Inflammatory Activity of Salicylate

Article metrics


SALICYLATE uncouples oxidative phosphorylation reactions1, and the possible relation of this major action on cellular metabolism, to other effects of the drugs is of great interest2. One of the most important properties of salicylate is its anti-inflammatory actions, both in rheumatic disease and in experimental inflammatory states3. Adams and Cobb4 observed a general parallelism between uncoupling activity and the inhibition of erythema in the guinea pig by a series of non-hormonal anti-rheumatic drugs, including salicylate. They suggested a possible connexion between uncoupling ability and therapeutic activity but found that 2 : 4-dinitrophenol, which is a more powerful uncoupling agent than salicylate, failed to affect the erythema test. We have observed that salicylate, but not 2 : 4-dinitrophenol, also modifies the response to the passive cutaneous anaphylaxis test in the guinea pig.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Brody, T. M., J. Pharmacol., 117, 39 (1956).

  2. 2

    Smith, M. J. H., J. Pharm. Pharmacol., 11, 705 (1959).

  3. 3

    Smith, W., and Humphrey, J. H., Brit. J. Exp. Path., 30, 560 (1949). Spector, W. G., Pharmacol. Rev., 10, 475 (1958).

  4. 4

    Adams, S. S., and Cobb, R., Nature, 181, 773 (1958).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

MARKS, V., SMITH, M. Anti-Inflammatory Activity of Salicylate. Nature 187, 610 (1960) doi:10.1038/187610a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.