Influence of 5-Hydroxytryptamine on Renal Function in Extracorporeal Circulation

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Abstract

A REDUCED renal blood flow and glomerular filtration-rate, despite a mean aortic pressure over the filtration-level, is a feature inherent to cardiopulmonary by-pass operations. Yet the maintenance of an adequate renal circulation is of primary importance in preventing ischæmic damage to the kidneys1, and much research has been directed toward this special problem in the use of heart-lung machines. Accurate measurements on the critical flow-rate in various forms of by-pass were recently reported by Morris et al. 2.

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FRICK, M. Influence of 5-Hydroxytryptamine on Renal Function in Extracorporeal Circulation. Nature 187, 609–610 (1960) doi:10.1038/187609a0

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