Effect of Cocaine on the Disposition of Noradrenaline labelled with Tritium

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COCAINE potentiates the responses of sympathetically innervated organs to adrenaline, noradrenaline and sympathetic nerve stimulation, and several explanations have been offered for this. Cannon and Rosenblueth1 suggested that cocaine might act by preventing the destruction of injected adrenaline, or of transmitter substance released from adrenergic nerves, and Torda2 and Trendelenburg3 obtained evidence in support of this hypothesis. Macmillan4 suggested that cocaine might prevent the uptake of catecholamines into tissue stores, and block their release from these stores, but his evidence was only indirect.

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  1. 1

    Cannon, W. B., and Rosenblueth, A., “Autonomic Neuro-effector Systems” (The Macmillan Co., New York, 1937).

  2. 2

    Torda, C., J. Pharmacol. and Exp. Therap., 78, 331 (1943).

  3. 3

    Trendelenburg, U., J. Pharmacol. and Exp. Therap., 125, 55 (1959).

  4. 4

    Macmillan, W. H., Brit. J. Pharmacol., 14, 385 (1959).

  5. 5

    Axelrod, J., Inscoe, J. K., Senoh, S., and Witkop, B., Biochim. Biophys. Acta, 27, 210 (1958).

  6. 6

    Axelrod, J., Weil-Malherbe, H., and Tomchick, R., J. Pharmacol. and Exp. Therap., 127, 251 (1959).

  7. 7

    Whitby, L. G., Weil-Malherbe, H., and Axelrod, J., Fed. Proc., 19, 295 (1960).

  8. 8

    Whitby, L. G., Weil-Malherbe, H., and Axelrod, J. (in preparation).

  9. 9

    Axelrod, J., and Tomchick, R., J. Biol. Chem., 233, 702 (1958).

  10. 10

    Burn, J. H., and Rand, M. J., J. Physiol. (Lond.), 144, 314 (1958).

  11. 11

    Carlsson, A., Rosengren, E., Bertler, A., and Nilsson, J., “Psychotropic Drugs”, 363 (Elsevier Pub. Co., Amsterdam, 1957).

  12. 12

    Bejrablaya, D., Burn, J. H., and Walker, J. M., Brit. J. Pharmacol., 13, 461 (1958).

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WHITBY, L., HERTTING, G. & AXELROD, J. Effect of Cocaine on the Disposition of Noradrenaline labelled with Tritium. Nature 187, 604–605 (1960) doi:10.1038/187604a0

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