A Potent New Benzothiadiazine Diuretic

Abstract

SINCE the discovery of chlorothiazide by Beyer et al. ¹, a number of chemically related compounds have been shown to possess similar natriuretic and chloruretic actions^2–4. Some of these agents, notably 3,4-dihydrochlorothiazide and its derivatives, differ from chlorothiazide primarily in a greater milligram potency, which may be associated with a longer duration of action⁵. These agents also inhibit carbonic anhydrase to a lesser extent than the unsaturated analogues, resulting in a lower urinary pH and generally a greater chloruretic response^5,6.