Presence of Immunologically Active Fragments after Proteolytic Degradation of Human γ-Globulin

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Abstract

ACCORDING to Lapresle, Kaminski and Tanner1, degradation of human serum albumin with trypsin or chymotrypsin yields several components with retained ability to give precipitation reactions with anti-human albumin antibodies. One of these components has been isolated by column electrophoresis in an agar medium and partially characterized by ultracentrifugation2. Porter3 isolated and characterized a similar component after chymotryptic hydrolysis of bovine serum albumin. After degradation of rabbit γ-globulin with papain, Porter also isolated a component showing inhibitory properties when added to a rabbit γ-globulin–anti-γ-globulin system4.

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References

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HANSON, L., JOHANSSON, B. Presence of Immunologically Active Fragments after Proteolytic Degradation of Human γ-Globulin. Nature 187, 599–600 (1960) doi:10.1038/187599a0

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