Structure of the Antibiotics PA114B-1 and PA114B-3

Article metrics

Abstract

WE wish to report the partial structures of PA114B-1 and PA114B-3, members of the PA114 group of synergistic antibiotics obtained from a strain of Streptomyces 1. Other reported synergistic antibiotic groups include streptogramin2, staphylomycin3, antibiotic E1294, and mikamycin5. Bioautographic comparisons by us6 and others4,5 have indicated identities and close similarities between various members of the groups. Table 1 summarizes these comparisons and embodies a proposed universal system of designations.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Celmer, W. D., and Sobin, B. A., “Antibiotics Annual 1955–1956”, 437 (Medical Encyclopedia, Inc., New York).

  2. 2

    Charney, J., Fisher, W. P., Curran, C., Machlowitz, R. A., and Tytell, A. A., Antibiotics and Chemother., 3, 1283 (1953).

  3. 3

    Vanderhaeghe, H., Van Dijck, P., Parmentier, G., and De Somer, P., Antibiotics and Chemother., 7, 606 (1957).

  4. 4

    Ball, S., Boothroyd, K. A., Lees, K. A., Raper, A. H., and Smith, E. L., Biochem. J., 68, 24 (1958).

  5. 5

    Arai, M., Okabe, K., Yonehara, H., and Umezawa, H., J. Antibiotics, 11, A, 21 (1958).

  6. 6

    Hobbs, D. C., and Celmer, W. D., Fed. Proc., 18, 246 (1959).

  7. 7

    Vanderhaeghe, H., and Parmentier, G., Bull. Soc. Chim. Belg., 68, 716 (1959).

  8. 8

    Sheehan, J. C., Zachau, H. G., and Lawson, W. B., J. Amer. Chem. Soc, 80, 3349 (1958).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

HOBBS, D., CELMER, W. Structure of the Antibiotics PA114B-1 and PA114B-3. Nature 187, 598–599 (1960) doi:10.1038/187598a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.