Structure of the Antibiotics PA114B-1 and PA114B-3

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WE wish to report the partial structures of PA114B-1 and PA114B-3, members of the PA114 group of synergistic antibiotics obtained from a strain of Streptomyces 1. Other reported synergistic antibiotic groups include streptogramin2, staphylomycin3, antibiotic E1294, and mikamycin5. Bioautographic comparisons by us6 and others4,5 have indicated identities and close similarities between various members of the groups. Table 1 summarizes these comparisons and embodies a proposed universal system of designations.

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    Sheehan, J. C., Zachau, H. G., and Lawson, W. B., J. Amer. Chem. Soc, 80, 3349 (1958).

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HOBBS, D., CELMER, W. Structure of the Antibiotics PA114B-1 and PA114B-3. Nature 187, 598–599 (1960) doi:10.1038/187598a0

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