Anti-Fertility Action of a Monoamine Oxidase Inhibitor

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AN earlier communication has directed attention to the anti-inflammatory properties of inhibitors of monoamine oxidase1. Similar properties for iproniazid, one such substance, have been described independently2. The similarities between the vascular events of implantation of the fertilized ovum and of the inflammatory reaction, together with the low toxicity of certain monoamine oxidase inhibitors, prompted the trial of these compounds as orally administered inhibitors of conception. The work was also stimulated by reports of the effect of 5-hydroxytryptamine and iproniazid in terminating pregnancy in mice3.

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  1. 1

    Spector, W. G., and Willoughby, D. A., Nature, 186, 162 (1960).

  2. 2

    Setnikar, I., Salvaterra, M., and Temelcou, O., Brit. J. Pharm., 14, 484 (1959).

  3. 3

    Poulson, E., Botros, M., and Robson, J. M., Science, 131, 1101 (1960).

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SPECTOR, W. Anti-Fertility Action of a Monoamine Oxidase Inhibitor. Nature 187, 514–515 (1960) doi:10.1038/187514a0

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