Abstract
AN earlier communication has directed attention to the anti-inflammatory properties of inhibitors of monoamine oxidase1. Similar properties for iproniazid, one such substance, have been described independently2. The similarities between the vascular events of implantation of the fertilized ovum and of the inflammatory reaction, together with the low toxicity of certain monoamine oxidase inhibitors, prompted the trial of these compounds as orally administered inhibitors of conception. The work was also stimulated by reports of the effect of 5-hydroxytryptamine and iproniazid in terminating pregnancy in mice3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Spector, W. G., and Willoughby, D. A., Nature, 186, 162 (1960).
Setnikar, I., Salvaterra, M., and Temelcou, O., Brit. J. Pharm., 14, 484 (1959).
Poulson, E., Botros, M., and Robson, J. M., Science, 131, 1101 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SPECTOR, W. Anti-Fertility Action of a Monoamine Oxidase Inhibitor. Nature 187, 514–515 (1960). https://doi.org/10.1038/187514a0
Issue Date:
DOI: https://doi.org/10.1038/187514a0
This article is cited by
-
Up-regulated monoamine oxidase in the mouse uterus during the peri-implantation period
Archives of Gynecology and Obstetrics (2011)
-
Effect of iproniazid on pregnancy
Experientia (1961)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.