Abstract
IN previous work it was found that after the injection of norepinephrine and epinephrine in rats, a new metabolite of these compounds was excreted in the urine1. Axelrod et al. 2 have isolated recently from the urine of rats a metabolite of epinephrine and norepinephrine, which they have identified as 3-methoxy-4-hydroxy phenyl glycol. We have found that after the intravenous infusion in cats of a mixture containing both norepinephrine-7-3H and epinephrine-1-14C, a similar compound was found in the liver and kidney of this animal.
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References
Goldstein, M., Friedhoff, A. J., and Sandler, G., Experientia (in the press).
Axelrod, J., Kopin, I. J., and Mann, J. D., Biochim. Biophys. Acta 36, 576 (1959).
Bertler, A., Carlsson, A., and Rosengren, E., Acta Physiol. Scand., 44, 273 (1958).
Bush, I. E., Biochem. J., 270 (1951).
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GOLDSTEIN, M., GERTNER, S. Formation of a New Metabolite of Epinephrine and Norepinephrine in Liver and Kidney. Nature 187, 147–148 (1960). https://doi.org/10.1038/187147a0
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DOI: https://doi.org/10.1038/187147a0
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