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Treatment of Leishmania donovani Infections with Surface-active Agents

Abstract

‘TRITON W.R. 1339’, an arylalkyl polyoxyethylene ether of phenol, prepared by Rohm and Haas Co., Philadelphia, is a non-toxic surface-active agent, and was shown to exert a suppressive effect in experimental tuberculosis of mice1. ‘Macrocyclon’ is the polyoxyethylene ether containing on average 12.5 ethylene oxide units per chain, formed by reaction of ethylene oxide with a macrocyclic phenol and possesses similar antituberculous activity2.

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References

  1. Cornforth, J. W., Hart, P. D'A., Rees, R. J. W., and Stock, J. A., Nature, 168, 150 (1951).

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  2. Cornforth, J. W., Hart, P. D'A., Nicholls, R. J., Rees, R. J. W., and Stock, J. A., Brit. J. Pharmacol. and Chemotherap., 10, 73 (1955).

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  3. Fulton, J. D., Ann. Trop. Med. and Parasitol., 38, 147 (1944).

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FULTON, J. Treatment of Leishmania donovani Infections with Surface-active Agents. Nature 187, 1129–1130 (1960). https://doi.org/10.1038/1871129b0

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