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A Transplantable Spontaneous Osteogenic Sarcoma observed in the Muscle Tissue of an Albino Mouse


OSTEOGENIC sarcomas attached to bone tissue have been reported in animals of different species. In 1936, Brues1 described a case of spontaneous osteogenic sarcoma in the jaw of a three-year-old grey rabbit. Barrett et al. reported an osteogenic sarcoma attached to the left femur of a C3H female mouse2. Osteogenic sarcomas have also been induced by radio-isotopes such as radium-226, strontium-90, calcium-45 (ref. 3) and strontium-89 (ref. 4). One case of osteogenic neoplasm arising from muscle tissue has been reported in man5. This tumour found in the thigh muscle had developed over a period of ten years and was believed to have followed an abscess in the muscle.

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  1. 1

    Brues, A. M., Amer. J. Cancer, 28, 587 (1936).

  2. 2

    Barrett, M. K., Dalton, A. J., Edwards, J. E., and Greenstein, J. P., J. Nat. Cancer Inst., 4, 389 (1943–44).

  3. 3

    Finkel, M. P., and Biskis, B. O., Unio Int. Contr. Cancer, 15, 99 (1959).

  4. 4

    Skoryna, S. C., and Kahn, D. S., Cancer, 12, 306 (1959).

  5. 5

    Vasilescu, C., Hristu, C., and Ivanitescu, G., Bull. et mem. Soc. med. d. hop. de Bucaresti, 17, 174 (1935).

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