Letter | Published:

Mast Cells and 5-Hydroxytryptamine in Precancerous Mouse Skin


A CURIOUS feature of carcinogenesis in the skin of the mouse is the intense mast-cell reaction which gradually develops in the dermis immediately under the painted hyperplastic epidermis. Cramer and Simpson1 observed that some of these new mast cells exhibit a golden-brown fluorescence in ultraviolet light, providing that the frozen section has also been treated with formaldehyde.

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  1. 1

    Cramer, W., and Simpson, W. L., Cancer Res., 4, 601 (1944).

  2. 2

    Riley, J. F., and West, G. B., J. Physiol. (Lond.), 120, 528 (1953).

  3. 3

    Benditt, E. P., Wong, R. L., Arase, M., and Roeper, E., Proc. Soc. Exp. Biol. (N.Y.), 90, 303 (1955).

  4. 4

    Riley, J. F., Experientia, 13, 141 (1958).

  5. 5

    Gomori, G., “Microscopic Histochemistry”, 128 (Univ. Chicago Press, 1952).

  6. 6

    Pearse, A. G. E., “Histochemistry—Theoretical and Applied”, second edit., 925 (Churchill, 1960).

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