Letter | Published:

Metabolism of Oxygen-15

Naturevolume 187page1121 (1960) | Download Citation



OXYGEN-15 has been prepared by deuteron bombardment of nitrogen molecules in the Medical Research Council cyclotron at Hammersmith Hospital. Gases labelled with this isotope, which has a half-life of only 2 min., can be inhaled into the lungs and detected by external scintillation counters. The initial counting-rate in a given region of the lung is proportional to the regional ventilation1, and the rate of removal from the region during breath-holding is a measure of the regional blood-flow2.

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  1. 1

    Dyson, N. A., Hugh-Jones, P., Newbery, G. R., Sinclair, J. D., and West, J. B., Brit. Med. J., i, 231 (1960).

  2. 2

    West, J. B., and Dollery, C. T., J. App. Physiol., 15, 405 (1960).

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  1. Department of Medicine, Postgraduate Medical School of London, Hammersmith Hospital, Ducane Road, London, W.12

    • C. T. DOLLERY
    •  & J. B. WEST


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