Letter | Published:

Interaction of Actinomycin with Deoxyribonucleic Acid

Naturevolume 187pages11121113 (1960) | Download Citation

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Abstract

IN previous papers, Kawamata et al. 1,2 have reported the carcinogenic effect of actinomycin. In the course of investigating the mechanisms of action of actinomycin, evidence was obtained that this antibiotic shows a specific interaction with deoxyribonucleic acid. In the following experiments actinomycin S was used3.

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References

  1. 1

    Kawamata, J., et al., Med. J. Osaka Univ., 8, 753 (1958).

  2. 2

    Kawamata, J., et al., Biken's J., 2, 105 (1959).

  3. 3

    Kawamata, J., and Fujita, H., Med. J. Osaka Univ., 8, 737 (1958); J. Antibiotics, Ser. A. (in the press).

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Affiliations

  1. Department of Chemotherapy, Research Institute for Microbial Diseases, Osaka University, and Institute for Cancer Research, Osaka University Medical School, Osaka

    • J. KAWAMATA
    •  & M. IMANISHI

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https://doi.org/10.1038/1871112a0

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