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Steric Factors affecting the Specificity of Polyglycosidases

Abstract

THE marked substrate specificity exhibited by enzymes has been related to a steric affinity between the molecule attacked and the attacking enzyme1. According to this concept, proper orientation of the substrate in the vicinity of the enzyme permits formation of an activated intermediate in which several points of contact may be established.

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References

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    For example, “The Enzymes”, ed. Boyer, P. D., Lardy, H., and Myrbäch, K., 1 (Academic Press, New York, 1959).

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    Pigman, W. W., “Advances in Enzymology”, 4, 41 (1944).

  3. 3

    Gottschalk, A., “Advances in Carbohydrate Chemistry”, 5, 49 (1950).

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    Parrish, F. W., Perlin, A. S., and Reese, E. T., Can. J. Chem. (in the press).

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    Morris, D. L., J. Biol. Chem., 142, 881 (1942).

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    Peat, S., Whelan, W. J., and Roberts, J. G., J. Chem. Soc., 3916 (1957).

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    Reese, E. T., and Mandels, M., Can. J. Microbiol., 5, 173 (1959).

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    Reese, E. T., Smakula, E., and Perlin, A. S., Arch. Biochem. Biophys., 85, 171 (1959).

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