Letter | Published:

Evidence for the Identity of Natriferin, the Frog Water-Balance Principle and Arginine Vasotocin

Naturevolume 187pages10301031 (1960) | Download Citation


  • An Erratum to this article was published on 05 November 1960


Maetz, Morel, and Lahlouh1 recently reported that pituitary extracts from amphibians and teleosts contain a principle which promotes the active transport of sodium by the isolated skin of the frog Rana esculenta. This factor cannot be oxytocin or a vasopressin since it has approximately ten times more activity on sodium transport than do mammalian extracts of similar oxytocic activity. Maetz et al. named this principle ‘natriferin’.


  1. 1

    Maetz, J., Morel, F., and Lahlouh, B., Nature, 184, 1236 (1959).

  2. 2

    Heller, H., J. Physiol., 100, 125 (1941).

  3. 3

    Heller, H., J. Physiol., 101, 317 (1942).

  4. 4

    Pickering, B. T., and Heller, H., Nature, 184, 1463 (1959).

  5. 5

    Munsick, R. A., Sawyer, W. H., and van Dyke, H. B., Endocrinol. (in the press).

  6. 6

    Katsoyannis, P. G., and du Vigneaud, V., J. Biol. Chem., 233, 1352 (1958).

  7. 7

    Katsoyannis, P. G., and du Vigneaud, V., Nature, 184, 1465 (1959).

  8. 8

    Sawyer, W. H., Endocrinol., 66, 112 (1960).

  9. 9

    Uranga, J., and Sawyer, W. H., Amer. J. Physiol. (in the press).

  10. 10

    Sawyer, W. H., Munsick, R. A., and van Dyke, H. B., Nature, 184, 1464 (1959).

  11. 11

    Ussing, H. H., and Zerahn, K., Acta Physiol. scandinav., 23, 110 (1951).

  12. 12

    Munsick, R. A., Endocrinol., 66, 451 (1960).

Download references

Author information


  1. Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York



  1. Search for WILBUR H. SAWYER in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.