Letter | Published:

Effect of Hydration on Hexobarbitone-induced Sleep in Mice


HYDRATION of laboratory animals and man produces a complex picture generally indicating increased excitability of the central nervous system. This is attributed to osmotic disturbances produced by fall of the extracellular electrolytes1. It is therefore interesting to find in albino mice that after hydration the sensitivity of the central nervous system to hexobarbitone was increased simultaneously. This conclusion is based on the results obtained from the following experiments.

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  1. 1

    Lancet, i, 425 (1953).

  2. 2

    Swinyard, E. A., Toman, J. E. P., and Goodman, L. S., J. Neurophysiol., 9, 47 (1946).

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