Letter | Published:

‘Eddy’ Diffusion in Chromatography (Reply)

Naturevolume 187pages10231024 (1960) | Download Citation



VARIANCES add1, for certain independent processes which, by virtue of an elementary random event, contribute directly to the variance. Lateral diffusion is not such a process. The variance is caused by non-equilibrium established by the difference in downstream velocity from point to point. Lateral diffusion acts to reduce this variance as can be seen by the inverse relationship between variance or plate height and diffusion coefficient. The random change in velocity which occurs along a given stream path, as found in packed columns but not in capillary columns, also reduces the variance. Both factors act independently to exchange molecules between fast- and slow-moving regions.

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  1. 1

    Klinkenberg, A., and Sjenitzer, F. (previous communication).

  2. 2

    Giddings, J. C., J. Chem. Phys., 31, 1462 (1959).

  3. 3

    Giddings, J. C., Nature, 184, 357 (1959).

  4. 4

    Giddings, J. C., J. Chromatography (in the press).

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  1. Department of Chemistry, University of Utah, Salt Lake City, 12, Utah



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