Specific Inhibition of Anti-Rh Serum by ‘Unnatural’ Sugars

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LANDSTEINER'S technique of specific serological inhibition has recently given valuable information about the structure of the A, B, H mucopoly-saccharides.1,2 It was reported by Hackel, Smolker and Fenske3 that anti-Rh sera were specifically inhibited by a number of ribonucleic acid derivatives, suggesting that the Rh antigens are at least partly nucleotide in nature.

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  1. 1

    Morgan, W. T. J., Naturwiss., 46, 181 (1959).

  2. 2

    Kabat, E. A., “Blood Group Substances.” (Academic Press, N.Y., 1956).

  3. 3

    Hackel, E., Smolker, R. E., and Fenske, S. A., Vox Sang., 3, 402 (1958).

  4. 4

    Mäkelä, O. “Studies in Hemagglutinins of Leguminosae Seeds”. (Helsinki, 1957). Cf. Boyd, W. C., Green, D. M., Fujinaga, D. M., Drabik, J. S., and Waszczenko–Zacharczenko, E., Vox Sang. (in the press).

  5. 5

    Boyd, W. C., Everhart, D. L., and McMaster, M. H., J. Immunol., 81, 414 (1958).

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BOYD, W., McMASTER, M. & WASZCZENKO-ZACHARCZENKO, E. Specific Inhibition of Anti-Rh Serum by ‘Unnatural’ Sugars. Nature 184, 989–990 (1959) doi:10.1038/184989a0

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