Hydrolysis of ‘Heated’ Hæmoglobin

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A DIMINISHED rate of alkaline denaturation of hæmoglobin is not confined to fœtal hæmoglobin only, as was already found by Singer et al. 1. Künzer2 in a survey on the occurrence of ‘fœtal’ hæmoglobin in various blood disorders found an alkali-resistant fraction in the anæmia developing after burns. Our observations have confirmed Künzer's and it has been found that this minor hæmoglobin abnormality develops during the first few hours after the burn and persists for some time. This abnormality develops before that of clinical anæmia and involves the patients' own and transfused cells. The detailed results of this work will be published elsewhere.

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  1. 1

    Singer, K., Chernoff, A. I., and Singer, L., Blood, 6, 413 (1951).

  2. 2

    Künzer, W., Z. Kinderh., 76, 58 (1954).

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    Ingram, V. M., Biochim. Biophys. Acta, 28, 539 (1958).

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    Meyer, H., Biochem. J., 67, 333 (1957).

  5. 5

    Löhr, G. W., Waller, H. D., Karges, O., Sehlegel, B., and Müller, A. A., Klin. Wschr., 36, 1008 (1958).

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BAAR, S. Hydrolysis of ‘Heated’ Hæmoglobin. Nature 184, 986–987 (1959) doi:10.1038/184986b0

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