Complex Formation of Chlorpromazine with Flavins

Article metrics


IN previous reports1,2 concerning the mechanism of inhibition of D-amino-acid oxidase, the formation of a complex of the inhibitor and the coenzyme, flavin adenine dinucleotide, was described. Experiments with chlorpromazine, however, indicated a different mechanism of inhibition.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Yagi, K., Okuda, J., Ozawa, T., and Okada, K., Science, 124, 273 (1956); Biochim. Biophys. Acta (in the press).

  2. 2

    Yagi, K., Okuda, J., Ozawa, T., and Okada, K., Biochem. Z., 328, 492 (1957).

  3. 3

    Yagi, K., Nagatsu, T., and Ozawa, T., Nature, 177, 891 (1956).

  4. 4

    Szent-Györgyi, A., ‘Bioenergetics’, 118 (Academic Press, 1957).

  5. 5

    Yagi, K., Ozawa, T., Ando, M., and Nagatsu, T., (unpublished results).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

YAGI, K., OZAWA, T. & NAGATSU, T. Complex Formation of Chlorpromazine with Flavins. Nature 184, 982–983 (1959) doi:10.1038/184982a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.