Complex Formation of Chlorpromazine with Flavins

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Abstract

IN previous reports1,2 concerning the mechanism of inhibition of D-amino-acid oxidase, the formation of a complex of the inhibitor and the coenzyme, flavin adenine dinucleotide, was described. Experiments with chlorpromazine, however, indicated a different mechanism of inhibition.

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References

  1. 1

    Yagi, K., Okuda, J., Ozawa, T., and Okada, K., Science, 124, 273 (1956); Biochim. Biophys. Acta (in the press).

  2. 2

    Yagi, K., Okuda, J., Ozawa, T., and Okada, K., Biochem. Z., 328, 492 (1957).

  3. 3

    Yagi, K., Nagatsu, T., and Ozawa, T., Nature, 177, 891 (1956).

  4. 4

    Szent-Györgyi, A., ‘Bioenergetics’, 118 (Academic Press, 1957).

  5. 5

    Yagi, K., Ozawa, T., Ando, M., and Nagatsu, T., (unpublished results).

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YAGI, K., OZAWA, T. & NAGATSU, T. Complex Formation of Chlorpromazine with Flavins. Nature 184, 982–983 (1959) doi:10.1038/184982a0

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