Thiamine-sparing Action of Sorbitol in Rats and Mice

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DEFICIENCY of thiamine may be prevented in rats if they are given sorbitol. Administration of sorbitol to deficient rats cures the deficiency; withdrawal of the sorbitol leads to deficiency1. All these results have now been found also in mice (Fig. 1). Mice, like rats, also showed an enlarged cæcum when they were fed diets with sorbitol (Table 1).

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  1. 1

    Morgan, T. B., and Yudkin, J., Nature, 180, 543 (1957).

  2. 2

    Morgan, T. B., and Yudkin, J., Chem. and Indust., 37 (1959).

  3. 3

    Barnes, R. H., Fiala, G., McGehee, B., and Brown, A., J. Nut., 63, 489 (1957).

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MORGAN, T., YUDKIN, J. Thiamine-sparing Action of Sorbitol in Rats and Mice. Nature 184, 909–910 (1959) doi:10.1038/184909a0

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