Neuromuscular Blocking Action of some Antibiotics

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CURARE-LIKE effects due to streptomycin and neomycin have been reported1–3. These two antibiotics have been shown to be capable of exerting a curariform block of the neuromuscular transmission2–4. One of us (G.B.) observed that some patients under heavy antibiotic treatment were more sensitive to the muscular relaxant action of d-tubocurarine. We have therefore begun to study the influence exerted by the most widely used antibiotics on the sensitivity of rabbits to the paralysing activity of curarizing drugs.

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  1. 1

    Loder, R. E., and Walker, G. F., Lancet, i, 812 (1959).

  2. 2

    Pittinger, G. B., and Long, J. P., Antibiotics and Chemotherapy, 8, 198 (1958).

  3. 3

    Foldes, F. F., Anæsthesia, 13, 191 (1958).

  4. 4

    Brazil, O. V., and Corrado, A. P., J. Pharmacol., 120, 452 (1957).

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BEZZI, G., GESSA, G. Neuromuscular Blocking Action of some Antibiotics. Nature 184, 905–906 (1959) doi:10.1038/184905a0

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