Abstract
CURARE-LIKE effects due to streptomycin and neomycin have been reported1–3. These two antibiotics have been shown to be capable of exerting a curariform block of the neuromuscular transmission2–4. One of us (G.B.) observed that some patients under heavy antibiotic treatment were more sensitive to the muscular relaxant action of d-tubocurarine. We have therefore begun to study the influence exerted by the most widely used antibiotics on the sensitivity of rabbits to the paralysing activity of curarizing drugs.
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References
Loder, R. E., and Walker, G. F., Lancet, i, 812 (1959).
Pittinger, G. B., and Long, J. P., Antibiotics and Chemotherapy, 8, 198 (1958).
Foldes, F. F., Anæsthesia, 13, 191 (1958).
Brazil, O. V., and Corrado, A. P., J. Pharmacol., 120, 452 (1957).
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BEZZI, G., GESSA, G. Neuromuscular Blocking Action of some Antibiotics. Nature 184, 905–906 (1959). https://doi.org/10.1038/184905a0
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DOI: https://doi.org/10.1038/184905a0
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