Glutamic-Pyruvic Transaminase in Rabbit's Long Bones

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THE finding that a transamination process is operative in metaphyseal cartilage of growing animals1 led to drawn some relationship between protein metabolism and mineralization2. Moreover, the observation that cortisone treatment which is known to inhibit skeletal development3 probably through a blocking activity on sulphate incorporation in the mucopolysaccharides4 of the organic matrix, also decreases the activity of glutamic-oxalacetic transaminase in metaphyseal cartilage5, suggests an active participation of transamination to osteogenesis, or at least in one of the metabolic processes leading to mineralization.

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TESSARI, L., PARRINI, L. Glutamic-Pyruvic Transaminase in Rabbit's Long Bones. Nature 184, 904 (1959) doi:10.1038/184904a0

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