An Antimetabolic Action of Vitamin K

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Abstract

IN recent studies in vivo and in vitro, we have shown that the K vitamins (K1, K2, phthiocol, menadione and ‘Synkavit’) inhibit the synthesis of nicotinic acid at the stage 3-hydroxyanthranilic acid→quinolinic acid. We suggested that the mechanism of inhibition is competition between vitamin K and 3-hydroxyanthranilic acid, that is, the K vitamins exert antimetabolitic action on the substrate of the reaction catalysed by 3-hydroxyanthranilic acid oxidase. On the basis of this hypothesis, investigations were undertaken to determine if the inhibition of 3-hydroxyanthranilic acid oxidase produced in vivo by administration of menadione or ‘Synkavit’ could be reversed by subsequent administration of 3-hydroxyanthranilic acid. The results of these experiments demonstrated the capacity of 3-hydroxyanthranilic acid to overcome the inhibitory effect of vitamin K.

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References

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QUAGLIARIELLO, E., SACCONE, C., RINALDI, E. et al. An Antimetabolic Action of Vitamin K. Nature 184, 820–821 (1959) doi:10.1038/184820a0

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