Presence of Behenic Acid in Sphingomyelin from Horse Spinal Cord

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IT is known that sphingomyelin from various animal tissues contains lignoceric, nervonic, stearic and palmitic acids as the component fatty acids. We have found a considerable amount of behenic acid together with nervonic, stearic and palmitic acid in sphingomyelin which was prepared from horse spinal cord. Cerebroside from spleen of Gaucher's disease was reported to have behenic acid as a constituent by Klenk1 and Rosenberg et al. 2, and sphingomyelin from brain to have a very small amount of the acid by Rennkamp3. The present study describes the presence of behenic acid as the essential constituent in sphingomyelin from normal animal tissue.

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    Klenk, E., Z. physiol. Chem., 267, 128 (1940–41).

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    Rosenberg, A., and Chargaff, E., J. Biol. Chem., 233, 1323 (1958).

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    Rennkamp, F., Z. physiol. Chem., 284, 215 (1949).

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    Thannhauser, S. J., Benotti, J., and Boncoddo, N. F., J. Biol. Chem., 166, 677 (1946).

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    Klenk, E., and Rennkamp, F., Z. physiol. Chem., 267, 145 (1940–41).

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    Meiklejohn, R. A., Meyer, R. J., Aronovic, S. M., Schuette, H. A., and Meloch, V. W., Anal. Chem., 29, 329 (1957).

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    Fujino, Y., and Negishi, T., Bull. Agr. Chem. Soc. Japan (in preparation).

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FUJINO, Y., NEGISHI, T. Presence of Behenic Acid in Sphingomyelin from Horse Spinal Cord. Nature 184, 817–818 (1959) doi:10.1038/184817a0

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