Letter | Published:

Effects of Methylthiouracil or Thyroidectomy on Activation of Pituitary Acid Phosphatases in vitro by Whole Hypothalamic Extract

Abstract

IN EARLIER experiments1 it was shown that incubation of whole rat pituitaries in vitro in whole aqueous hypothalamic extract increased pituitary acid phosphatase activity. In further experiments2–5 evidence has been submitted in support of the view that a relationship exists between activation of pituitary acid phosphatases in vivo and formation of the thyreotrophic hormone and that the presumed hypothalamic humoral factor activating pituitary acid phosphatases in vitro is related to thyroid-stimulating hormone secretion. The present communication gives the results of experiments investigating the extent to which the influence of hypothalmic extract on acid phosphatases in the rat pituitary in vitro can be modified by previous administration of methylthiouracil to hypothalamus donor rats or by previous thyroidectomy of these animals.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Charvat, J., Schreiber, V., and Kmentova, V., Nature, 182, 62 (1958).

  2. 2

    Schreiber, V., and Kmentova, V., Physiol Bohemoslov. (in the press).

  3. 3

    Schreiber, V., and Kmentova, V., Acta Biologica Hung. 9, 285 (1959).

  4. 4

    Schreiber, V., and Kmentova, V., Endokrinologie, 38, 69 (1959).

  5. 5

    Schreiber, V., and Kmentova, V., Folia Biologica, 5, 272 (1959).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.