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Effects of Methylthiouracil or Thyroidectomy on Activation of Pituitary Acid Phosphatases in vitro by Whole Hypothalamic Extract


IN EARLIER experiments1 it was shown that incubation of whole rat pituitaries in vitro in whole aqueous hypothalamic extract increased pituitary acid phosphatase activity. In further experiments2–5 evidence has been submitted in support of the view that a relationship exists between activation of pituitary acid phosphatases in vivo and formation of the thyreotrophic hormone and that the presumed hypothalamic humoral factor activating pituitary acid phosphatases in vitro is related to thyroid-stimulating hormone secretion. The present communication gives the results of experiments investigating the extent to which the influence of hypothalmic extract on acid phosphatases in the rat pituitary in vitro can be modified by previous administration of methylthiouracil to hypothalamus donor rats or by previous thyroidectomy of these animals.

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  1. 1

    Charvat, J., Schreiber, V., and Kmentova, V., Nature, 182, 62 (1958).

  2. 2

    Schreiber, V., and Kmentova, V., Physiol Bohemoslov. (in the press).

  3. 3

    Schreiber, V., and Kmentova, V., Acta Biologica Hung. 9, 285 (1959).

  4. 4

    Schreiber, V., and Kmentova, V., Endokrinologie, 38, 69 (1959).

  5. 5

    Schreiber, V., and Kmentova, V., Folia Biologica, 5, 272 (1959).

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