Letter | Published:

Sex Difference in Ethanol Tolerance of Rats


IN experiments on factors which influence the behaviour of rats in a simple functional test during alcohol intoxication, it was observed that after identical treatment the performance of young, sexually mature females was less impaired than was the performance of males. In testing, a record is made of the sliding angle on a tilted plane with a rough surface. The sliding angle is a linear function of alcohol dose in the approximate range of 0–8 mgm. ethanol/gm. body-weight, orally administered. A full description of the test has been given elsewhere.1

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  1. 1

    Arvola, A., Sammalisto, L., and Wallgren, H., Quart. J. Stud. Alc., 19, 563 (1958).

  2. 2

    Newman, E. J. and Newman, H. W., Stanford Med. Bull., 11, 96 (1953).

  3. 3

    Ijiri, J., Mitt. med. Akad. Kioto, 26, 813 (1939).

  4. 4

    Goldberg, L. and Störtebecker, T. P., Acta Physiol. Scand., 5, 289 (1943).

  5. 5

    Angelucci, L., Nature, 181, 967 (1958).

  6. 6

    Hoffman, R. A., and Zarrow, M. X., Amer. J. Physiol., 193, 547 (1958).

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