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Increase in the γ-Aminobutyric Acid Content of Rat Brain After Ingestion of Ethanol


γ-AMINOBUTYRIC acid is present in relatively large amounts in the mammalian central nervous system, where it exists chiefly in the free form 1,2. The formation of this amino-acid in brain tissue takes place by the decarboxylation of L-glutamic acid 1,3,4. There are in the literature several reports of a number of substances, mainly hydrazides, which lower the central nervous system level of γ-aminobutyric acid. In addition, a few substances, like diphenylhydantion and acetazoleamide, and some conditions have been reported to elevate the brain γ-aminobutyric acid content 5.

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  1. 1

    Roberts, E., and Frankel, S., J. Biol. Chem., 187, 55 (1950).

  2. 2

    Awapara, J., Landua, A. J., Fuerst, R., and Seale, B., J. Biol. Chem., 187, 35 (1950).

  3. 3

    Wingo, W. J., and Awapara, J., J. Biol. Chem., 187, 267 (1950).

  4. 4

    Roberts, E., and Frankel, S., J. Biol. Chem., 188, 789 (1951); ibid., 190, 505 (1951).

  5. 5

    Woodbury, D. M., and Vernadakis, A., Fed. Proc., 17, 420 (1958).

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