Abstract
γ-AMINOBUTYRIC acid is present in relatively large amounts in the mammalian central nervous system, where it exists chiefly in the free form 1,2. The formation of this amino-acid in brain tissue takes place by the decarboxylation of L-glutamic acid 1,3,4. There are in the literature several reports of a number of substances, mainly hydrazides, which lower the central nervous system level of γ-aminobutyric acid. In addition, a few substances, like diphenylhydantion and acetazoleamide, and some conditions have been reported to elevate the brain γ-aminobutyric acid content 5.
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HÄKKINEN, HM., KULONEN, E. Increase in the γ-Aminobutyric Acid Content of Rat Brain After Ingestion of Ethanol. Nature 184, 726 (1959). https://doi.org/10.1038/184726a0
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DOI: https://doi.org/10.1038/184726a0
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