Letter | Published:

Increase in the γ-Aminobutyric Acid Content of Rat Brain After Ingestion of Ethanol

Abstract

γ-AMINOBUTYRIC acid is present in relatively large amounts in the mammalian central nervous system, where it exists chiefly in the free form 1,2. The formation of this amino-acid in brain tissue takes place by the decarboxylation of L-glutamic acid 1,3,4. There are in the literature several reports of a number of substances, mainly hydrazides, which lower the central nervous system level of γ-aminobutyric acid. In addition, a few substances, like diphenylhydantion and acetazoleamide, and some conditions have been reported to elevate the brain γ-aminobutyric acid content 5.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Roberts, E., and Frankel, S., J. Biol. Chem., 187, 55 (1950).

  2. 2

    Awapara, J., Landua, A. J., Fuerst, R., and Seale, B., J. Biol. Chem., 187, 35 (1950).

  3. 3

    Wingo, W. J., and Awapara, J., J. Biol. Chem., 187, 267 (1950).

  4. 4

    Roberts, E., and Frankel, S., J. Biol. Chem., 188, 789 (1951); ibid., 190, 505 (1951).

  5. 5

    Woodbury, D. M., and Vernadakis, A., Fed. Proc., 17, 420 (1958).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.