Abstract
WORK on the influence of different chemical compounds on the reaction between blood group receptors of red cells and the corresponding antibodies has been published; but the action of antibiotics on this reaction, however, has not yet been fully examined except by Neter et al. 1, who described the effect of antibiotics on enterobacterial lipopolysaccharides utilizing hæmagglutination and hæmolysis reactions. Our chance discovery of the inhibiting effect of a streptomycin solution on the reaction between anti-D antibodies and D-positive erythrocytes led us to study the effect of different streptomycin concentrations on the antigen-antibody interaction in blood group systems. For our experiments we used streptomycin of Czechoslovak origin (‘Streptomycinum sulphuricum’, Penicillin Works, Prague). The different streptomycin concentrations were prepared by diluting 1 gm. of streptomycin in 2, 5, 10, 20, 50, 80 and 100 ml. of saline. Agglutinating sera of the systems A 1 A 2 BO, MN and Rh/Hr were chosen for the reaction; the red blood cells of the corresponding blood groups were washed three times in saline before use.
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Neter, E., Gorzynski, E. A., Westphal, O., and Luderitz, O., J. Immunol., 80, 66 (1958).
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KOUT, M., KUBICKOVA, Z. Influence of Streptomycin Solutions on the Interaction Between the Agglutinating Sera and the Corresponding Red Blood Cell Receptors. Nature 184, 639 (1959). https://doi.org/10.1038/184639a0
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DOI: https://doi.org/10.1038/184639a0
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