Abstract
CARCINOGENIC studies with rats using ‘bone seeking’ radioactive isotopes have shown that if the isotope is administered in several doses at intervals from a few days to one month a larger number of bone tumours develop than for a single injection of the same quantity of isotope1,2. This increase in the number of tumours is due to an increase in the probability of tumours developing and also to a reduction in the mortality of the rats from other causes both before and after the time of appearance of the first tumour.
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References
Kusma, J. F., and Zander, G., Arch. Path., 63, 198 (1957).
Barnes, L. L., Sperling, G., McCay, C. M., and Brown, C. E., Arch. Path., 66, 529 (1958).
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BLACKETT, N. An Effect of Dose Fractionation on the Incidence of Bone Tumours using Radioactive Phosphorus. Nature 184, 565–566 (1959). https://doi.org/10.1038/184565a0
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DOI: https://doi.org/10.1038/184565a0
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