Letter | Published:

Fate of Injected Dextran Labelled with Tritium in Mice


THE metabolism of the blood plasma substitute dextran has been widely studied during the last decade. It was early shown that starch-splitting enzymes do not break down dextran; but Grönwall found evidence that dextran is altered in the tissues to make it stainable with leuco-fuchsin without previous treatment with periodic acid. Cargill and Brunner2 showed that dextran labelled with carbon-14 is metabolized in mice since 14CO2 could be recovered from the expired air and labelled carbonates isolated from the urine.

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    Cargill, W. H., and Brunner, H. D., J. Pharm. Exp. Med., 103, 339 (1951).

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    Bull, J. P., Ricketts, C., Squire, J. R., Mayrock, W. D. A., Spooner, S. J. L., Mollison, P. L., and Paterson, J. C. S., Lancet, i, 134 (1949).

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