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Disappearance of the Erythropoietic Factor from Plasma of Anæmic Dogs after Nephrectomy


IN previous communications it was shown that bilateral nephrectomy abolished erythropoiesis in the dog1,2, whereas ureter ligation did not impair erythropoiesis despite a similar state of intoxication and malnutrition3. From these observations as well as the demonstration by Jacobson et al. 4 that an elevated erythropoietin-level was not obtained in hypoxic rats after nephrectomy, it was suggested that the kidney may be the site of production of one erythropoietic stimulating substance.

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  1. 1

    Naets, J. P., Experientia, 14, 74 (1958).

  2. 2

    Naets, J. P., Nature, 181, 1134 (1958).

  3. 3

    Naets, J. P., ibid., 182, 1516 (1958).

  4. 4

    Jacobson, L. O., Goldwasser, E., Fried, W., and Plzak, L. F., ibid., 179, 633 (1957).

  5. 5

    Naets, J. P., Proc. Soc. Exp. Biol. Med., (in the press).

  6. 6

    Fried, W., Plzak, L. F., Jacobson, L. O., Goldwasser, E., ibid., 94, 237 (1957).

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