Letter | Published:

Anticoagulant Activity of Human Arterial Mucopolysaccharides


THE isolation of acid mucopolysaccharide material from human aortic tissue was reported in a previous publication1 from this laboratory. Analysis of the isolated material2 and of components separated by paper electrophoresis3,4 indicated that the major part of the material consisted of chondroitin sulphate. The presence in the material of a fraction susceptible to the action of staphylococcal hyaluronidase2 and of a sulphated component containing both galactosamine and glucosamine4 was also observed. The isolation of heparitin sulphate from human aortic tissue has recently been reported by Linker, Hoffman, and Meyer5.

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  1. 1

    Dyrbye, M., and Kirk, J. E., J. Gerontol., 12, 20 (1957).

  2. 2

    Kirk, J. E., and Dyrbye, M., J. Gerontol., 12, 23 (1957).

  3. 3

    Dyrbye, M., Kirk, J. E., and Wang, I., J. Gerontol., 13, 149 (1958).

  4. 4

    Kirk, J. E., Wang, I., and Dyrbye, M., J. Gerontol., 13, 362 (1958).

  5. 5

    Linker, A., Hoffman, P., and Meyer, K., Fed. Proc., 17, 264 (1958).

  6. 6

    Jorpes, E., Holmgren, H., and Wilander, O., Ztschr. mik. anat. Forsch., 42, 279 (1937).

  7. 7

    Freeman, L., Engelberg, H., and Dudley, A., Amer. J. Clin. Path., 24, 599 (1954).

  8. 8

    Duguid, J. B., Practitioner, 175, 241 (1955).

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