Letter | Published:

Spectrophotofluorometric Assay of Griseofulvin


ALTHOUGH griseofulvin was isolated twenty years ago1 its value as a systemic anti-fungal agent was not appreciated until 1958, when Gentles2 reported that he had eradicated experimental ring-worm in guinea-pigs by its use in oral treatment. Clinical reports3–5 that have appeared since have evoked considerable interest among dermatologists and seem to have justified Gentles' optimism.

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  1. 1

    Oxford, A. E., Raistrick, H., and Simonart, P., Biochem. J., 33, 240 (1939).

  2. 2

    Gentles, J. C., Nature, 182, 476 (1958).

  3. 3

    Riehl, G., Meeting of the Austrian Dermatological Society, Vienna, (November 1958).

  4. 4

    Blank, H., and Roth, F. J., Meeting of the American Academy of Dermatology, Chicago (December 1958).

  5. 5

    Williams, D. I., Marten, R. H., and Sarkany, I., Lancet, ii, 1212 (1958).

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