Letter | Published:

N-Substituted 7-Methoxy-8-Aminomethylchromones and Flavones: New Brain-Stem Stimulants

Abstract

THE pharmacological screening of various chromone and flavone derivatives has led to the discovery of a new class of brain-stem stimulants, the N-substituted aminomethyl derivatives of these two nuclei, with the following structure: where R = H or alkyl radical, R′ = R″ = H or alkyl radicals, R′ and R″ can be a part of a cycle, R 2 = H or alkyl or aryl radical, R 3 = H or alkyl radical. The 3-methyl-7- methoxy-8-dimethylaminomethyl-flavone (Rec. 7-0267) seems to be the most interesting compound; its brain-stem stimulating activity is even higher than that of picrotoxin, the most potent brain-stem excitor so far known.

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References

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    Da Re, P., Verlicchi, L., and Setnikar, I. (in the press).

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