Letter | Published:

‘Eddy’ Diffusion in Chromatography

Abstract

AMONG the various diffusion and kinetic factors which are responsible for smearing chromatographic zones, the effect known as ‘eddy’ diffusion has been subject to the most controversy. Its contribution to the height equivalent to a theoretical plate (H) is usually assumed to depend only upon the packing of a column and to be independent of the velocity of flow. This assumption may be questioned by virtue of recent experimental work in chromatography1–3. An equation will be derived here which predicts ‘eddy’ diffusion to be dependent on velocity. This will be compared to the existing experimental evidence.

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References

  1. 1

    Bohemen, J., and Purnell, J. H., “Gas Chromatography”, 6, edit. D. H. Desty, (Butterworth, London, 1958).

  2. 2

    Littlewood, A. B., ibid., 23, 35.

  3. 3

    Glueckauf, E., “Vapor Phase Chromatography”, 29. edit. D. H. Desty (Butterworth, London, 1957).

  4. 4

    Beran, M. J., J. Chem. Phys., 27, 270 (1957).

  5. 5

    Giddings, J. C., J. Chem. Educ., 35, 588 (1958).

  6. 6

    Golay, M. J. E., “Gas Chromatography”, 36. edit. D. H. Desty (Butterworth, London, 1958).

  7. 7

    Glueckauf, E., ibid., 33.

  8. 8

    Keulemans, A. I. M., and Kwantes, A., “Vapor Phase Chromatography”, 15. edit. D. H. Desty (Butterworth, London).

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