Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Effect of Bacillus Calmette-Guérin Infection on Transplanted Tumours in the Mouse


DURING the growth of certain transplanted tumours considerable hyperactivity of the reticulo-endothelial system is observed.1 Similar alterations are also found in the first stage of experimental infections2, suggesting that the host response to foreign tissue and some infectious agents is closely related. Agents such as endotoxins, zymosan, products of the tubercle bacillus, and Bacillus Calmette-Guérin infection which enhance the activity of the reticulo-endothelial system3 and the capacity for antibody production4 also increase natural resistance to infection5. In light of these observations, we have attempted to alter the growth and lethality of various experimental tumours by agents known to possess the common property of stimulating the phagocytic capacity of the reticulo-endothelial system. One such agent, zymosan, has been demonstrated to increase significantly the regression rate of the mouse tumour, sarcoma 180 (S-180), under certain conditions6. The present report deals with the course of three transplantable tumours, S-180, carcinoma 755 (Ca 755), and Ehrlich ascites, in mice infected with Bacillus Calmette-Guérin.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout


  1. Biozzi, G., Stiffel, C., Halpern, B. N., and Mouton, D., Ann. Inst. Pasteur, 94, 681 (1958). Stern, K., and Duwelius, A., Proc. Amer. Assoc. Cancer Res., 2, 348 (1958). Old, L. J., Clarke, D. A., and Goldsmith, M., Proc. Amer. Assoc. Cancer. Res., 3, 49 (1959).

    CAS  Google Scholar 

  2. Biozzi, G., Halpern, B. N., Benacerraf, B., and Stiffel, C., “Physiopathology of the Reticulo-Endothelial System”, 204 (Blackwells Scientific Publications, Oxford, 1957). Boehme, D., and Dubos, R. J., J. Exp. Med., 107, 523 (1958).

    Google Scholar 

  3. Biozzi, G., Benacerraf, B., and Halpern, B. N., Brit. J. Exp. Path., 36, 226 (1955). Benacerraf, B., and Sebestyen, M., Fed. Proc., 16, 860 (1957). Biozzi, G., Benacerraf, B., Grumbach, F., Halpern, B. N., Levaditi, J., and Rist, N., Ann. Inst. Pasteur, 87, 291 (1954).

    CAS  PubMed  Google Scholar 

  4. Johnson, A. G., Gaines, S., and Landy, M., J. Exp. Med., 103, 225 (1956). Cutler, J. L., Fed. Proc., 18, 33 (1959). Halpern, B. N., Biozzi, G., Stiffel, C., and Mouton, D., C. R. Soc. Biol., 151, 758 (1958).

    Article  CAS  Google Scholar 

  5. Rowley, D., Lancet, i, 232 (1955). Dubos, R. J., and Schaedler, R., J. Exp. Med., 106, 703 (1957).

    Article  Google Scholar 

  6. Bradner, W. T., Clarke, D. A., and Stock, C. C., Cancer Res., 18, 347 (1958).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

OLD, L., CLARKE, D. & BENACERRAF, B. Effect of Bacillus Calmette-Guérin Infection on Transplanted Tumours in the Mouse. Nature 184, 291–292 (1959).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing