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Aneuploid Deoxyribonucleic Acid Content of Human Carcinomas


THE basic question of whether primary human malignant tumours consist of euploid or aneuploid cells has so far remained unanswered. It has been possible to determine the chromosome complement and deoxyribonucleic acid content only of human carcinomas with cells exfoliated in ascitic fluid1,2, human carcinomas transplanted in rats and hamsters3 and carcinomas grown in tissue culture.4,5 This lack of information can be attributed to several technical difficulties. Chromosome counts on solid human tumours cannot be generally obtained since a pretreatment with colchicine is impossible. The deoxy ribonucleic acid measurement by the one-wave-length method has so far been limited to interphase nuclei6 in which the occurrence of deoxyribonucleic acid synthesis prevents any conclusions in regard to euploidy or aneuploidy.

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STICH, H., EMSON, H. Aneuploid Deoxyribonucleic Acid Content of Human Carcinomas. Nature 184, 290–291 (1959).

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