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Response of Cholinergically Innervated Sweat Glands to Adrenaline and Noradrenaline


THAT the innervation of the sweat glands in the cat's foot pad is cholinergic has been recognized and generally accepted since the classical demonstration in 1934 by Dale and Feldberg1. However, sweat droplets have been seen to appear on the foot pad following intradermal or systemic injection of adrenaline or noradrenaline, most recently by Nakamura and Hatanaka2. The sweating is said to be minimal and not regularly reproducible3. In summarizing the situation, Rothman3 takes the view that the appearance of sweat droplets in response to adrenaline injection represents expulsion, due to myoepithelial contraction, rather than secretory activity. On the other hand a dual innervation, adrenergic and cholinergic, has been postulated by Kuno4.

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LLOYD, D. Response of Cholinergically Innervated Sweat Glands to Adrenaline and Noradrenaline. Nature 184, 277–278 (1959).

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