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Biosynthesis of Chondroitin Sulphates


LITTLE information is available regarding the biosynthesis of acid mucopolysaccharides. Knowledge of biosynthetic pathways to the chondroitin sulphates in particular is practically confined to the fact that glucose is utilized for both the hexosamine and uronic acid moieties1 and that 3′—phosphoadenosine 5′—phosphosulphate (PAPS) is involved in sulphate transfer2. Uridine intermediates are thought to take part by analogy to the synthesis of chitin, cellulose, and hyaluronic acid3.

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ADAMS, J. Biosynthesis of Chondroitin Sulphates. Nature 184, 274–275 (1959).

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