LITTLE information is available regarding the biosynthesis of acid mucopolysaccharides. Knowledge of biosynthetic pathways to the chondroitin sulphates in particular is practically confined to the fact that glucose is utilized for both the hexosamine and uronic acid moieties1 and that 3′—phosphoadenosine 5′—phosphosulphate (PAPS) is involved in sulphate transfer2. Uridine intermediates are thought to take part by analogy to the synthesis of chitin, cellulose, and hyaluronic acid3.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Roden, L., and Dorfman, A., J. Biol. Chem., 233, 1030 (1958).
D'Abramo, F., and Lipmann, F., Biochim. et Biopbys Acta., 25, 211 (1957).
Glaser, L. F., and Brown, D. H., Proc. U.S. Nat. Acad. Sci., 41, 253 (1955).
Meyer, K., Linker, A., Davidson, E. A., and Weissman, B., J. Biol. Chem., 205, 611 (1953).
Adams, J. B., Biochim. et Biopbys. Acta., 32, 559 (1959).
Meyer, K., and Palmer, J. W., J. Biol. Chem., 114, 689 (1936).
Orr, S. F., Biochim. et Biophys. Acta., 14, 173 (1954).
Malawista, I., and Schubert, M., J. Biol. Chem., 203, 535 (1958).
Dorfman, A., Markovitz, A., and Cifonelli, J. A., Fed. Proc., 17, (1958).
Rights and permissions
About this article
Cite this article
ADAMS, J. Biosynthesis of Chondroitin Sulphates. Nature 184, 274–275 (1959). https://doi.org/10.1038/184274a0
This article is cited by
The Cern Proton Synchrotron
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.