Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Heterogeneity of Human Fœtal Hæmoglobin: Incidence of Fœtal Variants in Singapore


THREE variants of fœtal hæmoglobin have so far been described primarily on the basis of electrophoretic mobility. These are known as: ‘Fessas and Papaspyrou’ type1, ‘Bart's’ type2, and ‘Alexandra’ type3. The ‘Fessas and Papaspyrou’ type appears to be relatively common and reports of its incidence have so far appeared from Singapore4 and Indonesia5. ‘Bart's’ hæmoglobin has been identified in specimens from Texas (Dr. B. Schneider) and Thailand (Dr. S. Tuchinda) (Drs. J. A. M. Ager and H. Lehmann, personal communication) and in one sample from Singapore.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others


  1. Fessas, Ph., and Papaspyrou, A., Science, 126, 1119 (1957).

    Article  ADS  CAS  Google Scholar 

  2. Ager, J. A. M., and Lehmann, H., Brit. Med. J., 1, 929 (1958).

    Article  CAS  Google Scholar 

  3. Fessas, Ph., Mastrokalos, N., and Fostiropoulos, G., Nature, 183, 30 (1959). Vella, F., Ager, J. A. M., and Lehmann, H., Nature, 183, 31 (1959).

    Article  ADS  CAS  Google Scholar 

  4. Vella, F., Indian J. Child Health, 7, 804 (1958); Communication to Centenary and Bicentenary Cong., University of Malaya, Singapore, December, 1958.

    Google Scholar 

  5. Lie-Injo, L. E., Nature, 183, 1125 (1959).

    Article  ADS  CAS  Google Scholar 

  6. Chernoff, A. I., New Engl. J. Med., 253, 322 (1955).

    Article  CAS  Google Scholar 

  7. Liang Chi-Chin, Biochem. J., 86, 552 (1957).

    Article  Google Scholar 

  8. Szeinberg, A., Sheba, C., and Adam, A., Nature, 181, 1256 (1958).

    Article  ADS  CAS  Google Scholar 

  9. Aksoy, M., Lehmann, H., and Lie-Injo, L. E., Lancet, 1, 792 (1957).

    Article  Google Scholar 

  10. Fessas, Ph., Mastrokalos, N., Nature, 183, 1261 (1959).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

VELLA, F. Heterogeneity of Human Fœtal Hæmoglobin: Incidence of Fœtal Variants in Singapore. Nature 184, 272–274 (1959).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing