Abstract
THE 2,4-dinitrophenylhydrazones of keto-acids are frequently used to identify these metabolic intermediates. The clear statement by Clift and Cook1 regarding the ready thermal decarboxylation of the 2,4-dinitrophenylhydrazones of oxaloacetic and acetoacetic acids has sometimes been overlooked, particularly in the use of melting points as a means of identification. Some of our observations bear on the problem.
References
Clift, F. P., and Cook, R. P., Biochem. J., 26, 1800 (1932).
Moriwaki, T., Katsuki, H., and Tanaka, S., J. Chem. Soc. Japan, 76, 1367 (1955).
Metzler, D. E., Olivard, J., and Snell, E. E., J. Amer. Chem. Soc., 76, 644 (1954).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TOKUSHIGE, A., COOK, E. Thermal Decarboxylation of Some Keto-Acid Hydrazones. Nature 184, 267 (1959). https://doi.org/10.1038/184267a0
Issue Date:
DOI: https://doi.org/10.1038/184267a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
