Abstract
SODIUM salicylate is known to cause a loss of potassium from rat diaphragms1. It is also known to uncouple oxidative phosphorylation2, and it is suggested1 that the loss of potassium is due to an interference with the energy supplies for active transport. If so, the inward movement of potassium should be decreased in the presence of salicylate and the outward movement unaltered or decreased as the intracellular concentration of potassium falls.
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Manchester, K. L., Randle, P. J., and Smith, G. H., Brit. Med. J. i, 1028 (1958).
Brody, T. M., J. Pharmacol. Exp. Therap., 117, 39 (1956).
Creese, R., Proc. Roy. Soc., B., 142, 497 (1954).
Harris, E. J., and Burn, G. P., Trans. Farad. Soc., 45, 508 (1949).
Rayner, B., and Weatherall, M., J. Physiol., 146, 392 (1959).
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HICKLIN, J. Salicylate and Potassium Fluxes of Rat Diaphragm. Nature 184, 2029 (1959). https://doi.org/10.1038/1842029a0
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DOI: https://doi.org/10.1038/1842029a0
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