Abstract
MUSCULAR dystrophy is an heritable disease characterized by progressive weakness and wasting of muscle, creatinuria1, and decreased ability of muscle to take up creatine2. The observation that the administration of 17α-ethyl-19-nortestosterone, an anabolic agent, augments markedly the synthesis of endogenous creatine3 led us to investigate the effect of this substance on the survival of dystrophic mice. The dystrophic mice are a strain 129 mutant which suffer from an hereditary disease resembling human muscular dystrophy in its natural history and gross and microscopic pathology4, in the electrolyte abnormalities of residual muscle5, and in the presence of abnormally high levels of aldolase in the serum.
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References
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DOWBEN, R. Prolonged Survival of Dystrophic Mice treated with 17α-EthyI-19-Nortestosterone. Nature 184, 1966–1967 (1959). https://doi.org/10.1038/1841966a0
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DOI: https://doi.org/10.1038/1841966a0
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